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https://www.selleckchem.com/products/gs-9973.html AIM The aims were to characterize pediatric medication errors and to identify the prevalence of known high-alert substances in these errors. METHODS All pediatric drug-related incident reports and complaints nationally reported to the Health and Social Care Inspectorate in Sweden 2011-2017 regarding inpatients were characterized by context and modal details. In addition, drug use at a university hospital was matched to local incident reports. Drug substances were classified using three high-alert lists. RESULTS On a national level, there were 160 reports (2.5 per 10,000 patients) in which the three high-alert lists were found in different degrees (17/35/47%). Morphine (n=12), vancomycin (n=11) and potassium (n=7) were most frequently involved. Eighty percent of the reports concerned patients aged 0-6 years. Intravenous was the most common route of administration (66%). On a university hospital level, the prevalence of all types of drug incidents reports was 1.7% among all inpatients. The prevalence of local incident reports involving high-alert substances was almost double that of non-alert substances. CONCLUSION Existing high-alert drug lists are relevant for pediatric inpatients. A higher awareness and usage of such lists among hospital staff prescribing, dispensing and administering drugs to children may have the potential to reduce medication errors. This article is protected by copyright. All rights reserved.OBJECTIVE Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's Disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non-motor DBS effects is not well characterized. By focusing on the affective domain, we systematically investigate the impact of electrode placement and associated structural connectivity on changes in depressive symptoms following STN-DBS which have been reported to improve, worsen or rem

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