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https://www.selleckchem.com/products/AZD7762.html The use of monoclonal antibodies directed against programmed cell death protein 1 (PD-1) and its ligand, programmed cell death 1 ligand 1 (PD-L1), widely extends to a large number of tumors such as melanoma, non-small cell lung, renal or lymphomas, among others. Some of them are already approved as first- or second-line treatment, as pembrolizumab, nivolumab or cemiplimab. Dostarlimab is an investigational humanized anti-PD-1 that is being developed both in monotherapy and as combination therapy, for gynecological tumors but also for lung cancer or melanoma. The preliminary results, particularly in endometrial cancer, show a high affinity against PD-1 with encouraging clinical activity. Here we summarize the development of this compound as well as the current preclinical and clinical data and potential future development. Anthropogenic climate change is a phenomenon that is becoming increasingly important in many areas such as economics and politics, but it also has great scientific relevance due to the important effects it has on people's health, the relationship between climate change and Health has caused an increase in the production of scientific knowledge about this topic and therefore the objective of this article was to provide an updated review of the open access scientific evidence, in the last five years, related to the effects of anthropogenic climate change in Public Health. A systematic review was conducted, in Spanish and English, in four non-subscription databases; using online thesaurus terms, the inclusion and exclusion criteria, an evaluation with the STROBE checklist were applied. Finally, 18 publications were analyzed. These showed the relationship between extreme events, such as heat and cold waves, with the increase in mortality from various causes, especially from heart attacks; the alteration of the rainy and drought periods as a determinant of various infectious diseases; air pollution from

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