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https://www.selleckchem.com/products/sf2312.html Deer antler velvet (DAV), Cornu Cervi Pantotrichum, has been known for the outstanding growth rate and used in extracted liquid form in oriental herbal medicine for the tissue regeneration. The DAV is also famous for the abundance of many different minerals, proteins, growth factors and interleukins. The immense amount of DAV is consumed to produce DAV extract in Asian countries. However, the mechanical strength and the morphologic features of DAV have been overlooked. In this study, we revisited the possibility of DAV as a bone tissue scaffold. We first obtained DAV particles via physical decellularization followed by levigation procedure and then applied to the fabrication of three-dimensional porous alginate/DAVP sponge through lyophilizing alginate/DAVP hydrogel as a potential bone tissue scaffold source. The morphological and physicochemical properties of alginate/DAVP sponge were characterized using UTM, SEM, FE-SEM, and FT-IR. The alginate-based highly porous sponge demonstrated the interconnected porous structure with DAVP and improved mechanical properties. We expected both alginate/DAVP and DAVP are potential for tissue engineering application.Physio-chemical surface properties to biomaterial has been attention in tissue engineering due to their properties on cell adhesion, proliferation, and differentiation. The object of this study is to evaluate the preosteoblast biological response on physio-chemical surface-layered 3D PCL scaffold and 3D PCL/β-TCP scaffold. 3D scaffolds were fabricated by FDM 3D printing. Physio-chemical surface of 3D scaffolds were prepared by oxygen plasma and amine plasma-polymerization, respectively. The results of this study demonstrated that amine plasma-treated 3D scaffold on adhesion, proliferation, and osteogenic differentiation of the MC3T3-E1 was significantly increased compared to the other scaffolds.In this manuscript, biological durability, cytotoxicity and MRI image contr

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