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https://www.selleckchem.com/products/abraxane-nab-paclitaxel.html Next, in a prostate-specific PTENp-/- mice, Ch-319 showed reduced weights of genitourinary apparatus as compared to DMSO treated controls. Histological studies indicated absence of neoplastic foci in Ch-319 treated prostates. Consistently, dephosphorylation of Akt-1, reduced expression of PRAS40 and androgen receptor and increase in FOXO3a were observed in treated group. Notably, no overt organ toxicity was noted in Ch-319 treated animals. Our studies identify Akt/FOXO3a signaling as a target of triphenyltin (IV) carboxylate Ch-319 and provide a molecular basis of its growth inhibitory effect in PCa cells. We propose that Ch-319 has the potential to be developed as an anticancer agent against PCa.Background Dysphagia is common and independently predicts death in ICU patients. Risk factors for dysphagia are largely unknown with sparse data available from mostly small cohorts without systematic dysphagia screening. Research question What are the key risk factors for dysphagia in ICU patients post invasive mechanical ventilation? Study design and methods Post-hoc analysis of data from a monocentric prospective observational study ("DYnAMICS") using comprehensive statistical models to identify potential risk factors for post-extubation dysphagia. 933 primary admissions of adult medical-surgical ICU patients (median age 65 years [IQR 54-73], n=666 (71%) male) were investigated in a tertiary care academic centre. Patients received systematic bedside screening for dysphagia within 3 hours post extubation. Dysphagia screening positivity (n=116) was followed within 24 hours by a confirmatory exam. Results After adjustment for confounders, baseline neurological disease (OR 4.45, 95%-CI 2.74-7.24, p less then 0.01), emergency admission (OR 2.04, 95%-CI 1.15-3.59, p less then 0.01), days on mechanical ventilation (OR 1.19, 95%-CI 1.06-1.34, p less then 0.01), days on renal replacement therapy (OR 1.1, 95%-CI 1-1.

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