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https://www.selleckchem.com/products/recilisib.html 003). No significant results were found by dividing the cohort using the positivity to anti-CCP and/or RF. CONCLUSIONS Earlier onset and a longer disease duration in anti-CarP positive patients might suggest they are specific risk factors for RA in this subgroup of patients. The correlation between the anti-CarP positivity at baseline and the reduction of disease activity during the first six months of treatment with abatacept allowed us to hypothesise that anti-CarP antibodies, but not anti-CCP and/or RF, could be used as a good clinical response predictor.OBJECTIVES To assess the long-term mortality and risk of cardiovascular events (CVE) among Danish patients with Takayasu's arteritis (TAK). METHODS Administrative registers with nationwide coverage were used to identify patients diagnosed with TAK in Denmark during 1994-2014 and construct an age- and gender-matched cohort of population-controls. CVE were identified by means of hospital discharge diagnoses and categorised as major or minor, based on severity. Cox regression analyses were used to calculate hazard ratios (HRs) for death and first-time hospitalisations for CVE as a measure of relative risk. RESULTS 79 patients with TAK were identified, corresponding to an incidence rate of 0.7 (95% confidence interval (CI) 0.6-0.9)/million/year. Median duration of follow-up in the TAK cohort was 6.4 (IQR 3.7-11) years. Mortality was significantly higher among the TAK patients than among the population controls during the first 3 years of follow-up [HR for death 8.0 (95% CI 3.0-21)], but not after >3 years [HR for death 0.5 (95% CI 0.1-3.5)]. Risk of CVE was significantly increased among TAK patients after ≤3 years [HR for major CVE 12 (95% CI 3.8-37), HR for minor CVE 19 (95% CI 7.5-50)] as well as after >3 years [HR for major CVE 7.6 (95% CI 2.8-21), HR for minor CVE 3.0 (95% CI 1.01-9.0)]. CONCLUSIONS Compared to the general population, patients with TAK experienc

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