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https://www.selleckchem.com/products/lee011.html The three polypyrrole (PPy) films with different mixture ratios, namely PPy1, PPy2, and PPy3, were synthesized by chemical oxidation with pyrrole and ferric chloride (FeCl3). The roughened plastic optical fiber (POF) taper assembled PPy films (POF-PPy1, POF-PPy2, and POF-PPy3) were facilely prepared and bentU shape structure for testing ethanol gas at room temperature. The morphologies of the PPy films and the roughened POF taper were studied using electron microscopy. The effect of the three PPy films on the gas response was investigated and the results showed that the POF-PPy2 exhibited a high sensitivity of 5.08 × 10-5 dB/ppm. The detection limit of the sensor was 140 ppm and its response and recovery times were 5 s and 8 s, respectively. The results also showed that as the bending radius decreased, the response and recovery times gradually shortened, while the output power increased. In addition, the proposed sensor has advantages of a low cost and simple structure.Topoisomerase I in eukaryotic cells is an important regulator of DNA topology. Its catalytic function is to remove positive or negative superhelical tension by binding to duplex DNA, creating a reversible single-strand break, and finally religating the broken strand. Proper maintenance of DNA topological homeostasis, in turn, is critically important in the regulation of replication, transcription, DNA repair, and other processes of DNA metabolism. One of the cellular processes regulated by the DNA topology and thus by Topoisomerase I is the formation of non-canonical DNA structures. Non-canonical or non-B DNA structures, including the four-stranded G-quadruplex or G4 DNA, are potentially pathological in that they interfere with replication or transcription, forming hotspots of genome instability. In this review, we first describe the role of Topoisomerase I in reducing the formation of non-canonical nucleic acid structures in the genome. We further disc

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