Yam Code
Sign up
Login
New paste
Home
Trending
Archive
English
English
Tiếng Việt
भारत
Sign up
Login
New Paste
Browse
Conclusions The large-calibre transanal drainage tube effectively prevented the occurrence of anastomotic leakage after anterior resection for rectal cancer and increased the safety of the surgery.Purpose To detect the expressions of CD74 and matrix metalloproteinase-9 (MMP-9) in colon adenocarcinomas, and to explore the relationship between the expressions and clinicopathological characteristics and prognosis. Methods 98 cases of colon adenocarcinoma tissues from patients who underwent colon cancer resection in the Sixth Affiliated Hospital, Sun Yat-sen University from January 2013 to March 2015 comprised the experimental group, while 71 cases of colon mucosa tissues from patients who underwent colon polypectomy during the same period comprised the control group. qRT-PCR was used to detect the expressions of CD44 and MMP-9 mRNAs in the two groups, in order to analyze their correlation in colon adenocarcinomas, and to also analyze their relationship with clinicopathological characteristics and prognosis. Results The expressions of CD74 and MMP-9 mRNAs in colon adenocarcinoma tissues were significantly higher than those in normal colon mucosa tissues (p0.05), but had significant correlation with lymph node metastasis and pathological stage (p less then 0.05). According to the average expressions of CD74 and MMP-9 mRNAs, the patients were divided into low and high expression groups. The 3-year survival rate of patients in the low expression group was significantly higher than that in the high expression group (p less then 0.05). Moreover, the expressions of CD74 and MMP-9 were positively correlated (r = 0.853, p less then 0.001). Conclusion CD74 and MMP-9 are highly expressed in colon adenocarcinomas, and their expressions are closely related to the pathological stage, lymph node metastasis and prognosis of colon adenocarcinoma patients. Therefore, they can be used as important biological markers for diagnosis and prognosis prediction of colon adenocarcinoma.Purpose KRAS mutations are associated with colorectal cancer survival whereas the role of body mass index (BMI) is less defined. Phase angle, which is more an indicator of cell integrity also has not been studied as prognostic and predictive factor. We evaluated the association between BMI, phase angle and colorectal cancer overall survival (OS), by KRAS mutation status and other prognostic for metastatic colorectal cancer. Methods This prospective study included 89 patients diagnosed with metastatic colorectal cancer in oncology and pathology departments. BMI and phase angle alpha were reported from the TANITA MC-780U mutifrequency segmental body composition analyzer at presentation at our department. KRAS mutation status was analyzed. Multivariate analysis was estimated from Cox proportional hazards models. Results High phase angle which indicated proper cell integrity was associated with good performance status, low T stage, low fat percent and high BMI. Overall response was statistically significant with left sided colon cancer and high BMI. On multivariate analysis, the factors maintaining statistical significance with OS were KRAS and overall response. High BMI was associated with higher OS in both mutated and wild groups without statistical significance. As regard progression-free survival (PFS), surgery, T stage, and lymphovascular invasion maintained statistical significance on multivariate analysis. Conclusion High phase angle was associated with improved performance status. High BMI was associated with improved OS in all KRAS subgroups.Purpose This study aimed to verify whether the regulation of miR-21 expression by lncRNA MALAT1 interferes with the biological behavior and mechanism of colon cancer cells. Methods RT-qPCR was used to detect the expression of MALAT1 in colon cancer and paracancerous tissues and different colon cancer cell lines (HT-29, SW480, SW620, CaCo-2). The relationship between MALAT1 and clinicopathological parameters of colon cancer patients and the interaction of MALAT1 and miR-21 by dual luciferase reporter gene detection were detected. Transwell invasion assay detected the invasive ability of colon cancer cells after MALAT1 inhibition and scratch assay detected the migration ability of colon cancer cells after MALAT1 inhibition. Subcutaneous tumor formation was detected in nude mice to measure the inhibition of the tumor size and volume of MALAT1 colon cancer cells. Results Compared with paracancerous tissues, MALAT1 expression was significantly increased in colon cancer tissues. MALAT1 expression was the highest in HT-29 colon cancer cell line. MALAT1 was specifically bound to miR-21 3' UTR. Inhibition of MALAT1 could inhibit colon cancer cell invasion and migration ability, and tumor formation in nude mice showed that the tumor volume and weight of the tumor-bearing mice were reduced after inhibiting the expression of MALAT1. Conclusion In conclusion, lncRNA MALAT1 plays an important role in the development of colon cancer. MALAT1 can regulate miR-21 to regulate the migration and invasion of colon cancer cells.Purpose The purpose of this study was to compare the long-term outcomes of laparoscopic and open sphincter-preserving total mesorectal excision (TME) for low rectal cancer (LRC) using propensity score matching (PSM). Methods The clinical and follow-up data of 169 patients with LRC who underwent sphincter-preserving TME at our institution between January 2011 and January 2014 were retrospectively analyzed. Patients were divided into laparoscopic and open group based on the surgical approach. https://www.selleckchem.com/products/rvx-208.html PSM including age, sex, body mass index, clinical stage, and American Society of Anesthesiologists score with a 11 ratio was subsequently performed. Sixty-eight patients in each group were ultimately included, and short- and long-term outcomes were compared between groups. Results Compared with the open group, the laparoscopic group had less intraoperative blood loss, more rapid postoperative recovery, and lower incidence of 30-day postoperative complications. However, there were no significant differences in severity of postoperative 30-day complications between the two groups. Both groups had no intraoperative or 30-day postoperative mortality. Regarding survival outcome, tumor recurrence rate, tumor recurrence site, 5-year overall survival, and 5-year disease-free survival, there were no significant differences between groups. Conclusion Laparoscopic sphincter-preserving TME can achieve long-term outcomes similar to those of open TME for LRC.
Paste Settings
Paste Title :
[Optional]
Paste Folder :
[Optional]
Select
Syntax Highlighting :
[Optional]
Select
Markup
CSS
JavaScript
Bash
C
C#
C++
Java
JSON
Lua
Plaintext
C-like
ABAP
ActionScript
Ada
Apache Configuration
APL
AppleScript
Arduino
ARFF
AsciiDoc
6502 Assembly
ASP.NET (C#)
AutoHotKey
AutoIt
Basic
Batch
Bison
Brainfuck
Bro
CoffeeScript
Clojure
Crystal
Content-Security-Policy
CSS Extras
D
Dart
Diff
Django/Jinja2
Docker
Eiffel
Elixir
Elm
ERB
Erlang
F#
Flow
Fortran
GEDCOM
Gherkin
Git
GLSL
GameMaker Language
Go
GraphQL
Groovy
Haml
Handlebars
Haskell
Haxe
HTTP
HTTP Public-Key-Pins
HTTP Strict-Transport-Security
IchigoJam
Icon
Inform 7
INI
IO
J
Jolie
Julia
Keyman
Kotlin
LaTeX
Less
Liquid
Lisp
LiveScript
LOLCODE
Makefile
Markdown
Markup templating
MATLAB
MEL
Mizar
Monkey
N4JS
NASM
nginx
Nim
Nix
NSIS
Objective-C
OCaml
OpenCL
Oz
PARI/GP
Parser
Pascal
Perl
PHP
PHP Extras
PL/SQL
PowerShell
Processing
Prolog
.properties
Protocol Buffers
Pug
Puppet
Pure
Python
Q (kdb+ database)
Qore
R
React JSX
React TSX
Ren'py
Reason
reST (reStructuredText)
Rip
Roboconf
Ruby
Rust
SAS
Sass (Sass)
Sass (Scss)
Scala
Scheme
Smalltalk
Smarty
SQL
Soy (Closure Template)
Stylus
Swift
TAP
Tcl
Textile
Template Toolkit 2
Twig
TypeScript
VB.Net
Velocity
Verilog
VHDL
vim
Visual Basic
WebAssembly
Wiki markup
Xeora
Xojo (REALbasic)
XQuery
YAML
HTML
Paste Expiration :
[Optional]
Never
Self Destroy
10 Minutes
1 Hour
1 Day
1 Week
2 Weeks
1 Month
6 Months
1 Year
Paste Status :
[Optional]
Public
Unlisted
Private (members only)
Password :
[Optional]
Description:
[Optional]
Tags:
[Optional]
Encrypt Paste
(
?
)
Create New Paste
You are currently not logged in, this means you can not edit or delete anything you paste.
Sign Up
or
Login
Site Languages
×
English
Tiếng Việt
भारत