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https://www.selleckchem.com/Bcl-2.html To describe the impact of mental health on the ability to function optimally among older adults experiencing mental health issues. This study had a descriptive qualitative design. Six older females with a Hospital Anxiety and Depression Scale (HADS) score of ≥8 on either of the subscales (depression or anxiety) participated in individual interviews. All data were analysed using a phenomenological approach influenced by Giorgi. The phenomenological analysis led to a structured synthesis comprising the following three themes (a) life situations affecting mental health, (b) consequences of mental health in everyday life and (c) strategies for maintaining mental health. The phenomenological analysis led to a structured synthesis comprising the following three themes (a) life situations affecting mental health, (b) consequences of mental health in everyday life and (c) strategies for maintaining mental health. To demonstrate that long-circulating PEGylated liposomal prednisolone is a safe and effective therapy in patients with active moderate-to-severe Graves' orbitopathy. Open-label, proof-of-concept, multicentre pilot study. Ten patients with moderate-to-severe Graves's orbitopathy, who were euthyroid for at least three months. Long-circulating PEGylated liposomal prednisolone 150mg was administered intravenously twice, with 2-week interval. Total follow-up was 12months, with visits at baseline, week 2, 6, 13, 26 and 52. Physical, laboratory and ophthalmological examinations were performed. Response to treatment was defined as a reduction in Clinical Activity Score by ≥2 points; palpebral aperture by ≥3mm; soft tissue signs by ≥2 grades; exophthalmos by ≥2mm; and motility by >8 degrees or improvement in diplopia score. A response was sustained when equally observed at weeks 6 and 13. One patient achieved a sustained response according to the predetermined definition. All patients showed a decrease in Clinical Activity Score after

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