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https://www.selleckchem.com/products/ly2109761.html es occur may be an interesting research lead in order to find possible explanations for IBS development.Breast cancer is the leading ‎cause of death from cancer ‎among women. Higher ‎consumption ‎of ‎dietary ‎marine n-3 long-chain ‎polyunsaturated fatty acids ‎‎(LC-PUFAs) is associated ‎with a ‎‎lower risk of breast ‎cancer. Eicosapentaenoic ‎acid (EPA) and ‎docosahexaenoic acid (DHA) ‎‎are ‎two n-3 LC-PUFAs found ‎in fish and exert anticancer ‎effects. In this study, ‎natural ‎marine-‎derived ‎lecithin that is rich in ‎various polyunsaturated fatty acids (PUFAs) was extracted ‎from salmon heads and ‎‎transformed ‎into ‎nanoliposomes. These ‎nanoliposomes were ‎characterized and cultured ‎with ‎two breast ‎cancer ‎lines (MCF-7 and MDA-MB-‎‎231). The nanoliposomes ‎decreased the ‎proliferation ‎and ‎the stiffness of both ‎cancer cell types. These ‎results suggest that marine-derived lecithin possesses ‎‎anticancer properties, ‎which may have an impact ‎on developing new ‎‎liposomal delivery ‎‎strategies for breast cancer ‎treatment.Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype. Much of our molecular understanding in senescent cell biology comes from studies using mammalian cell lines exposed to stress or extended culture periods. While less well understood mechanistically, senescence in vivo is becoming appreciated for its numerous biological implications, both in the context of beneficial processes, such as development, tumor suppression, and wound healing, and in detrimental conditions, where senescent cell accumulation has been shown to contribute to aging and age-related diseases. Importantly, clearance of senescent cells, through either genetic or pharmacological means, has been shown to not only extend the healthspan of prematurely and naturally aged mice but also attenuate patho

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