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https://www.selleckchem.com/EGFR(HER).html 6622-0.8034 for 5 years. Multivariate COX regression analysis indicated that AMLRS was an independent prognostic factor in four data sets. Nomogram combining the AMLRS and two clinical parameters performed well in predicting 1-year, 3-year and 5-year OS. Finally, we created a web-based prognostic model to predict the prognosis of AML patients (https//tcgi.shinyapps.io/amlrs_nomogram/). © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.The long non-coding RNA Eosinophil Granule Ontogeny Transcript (EGOT) has been reported to inhibit the proliferation and migration of glioma cells and promote the development and progression of gastric cancer through the Hedgehog (Hh) signaling pathway. This study was conducted to assess the role of EGOT in the progression of breast cancer. We observed that EGOT is significantly downregulated in breast cancer tissues and cell lines and EGOT expression is negatively correlated with the Ki67 expression. Overexpression of EGOT in BT549 cells decreased cell viability and migration. Additionally, overexpression of EGOT resulted in decreases in expression of key genes in the Hh pathway, including Gli1, SMO, PTCH1 and HHIP. Breast cancer tissues exhibited an increase in Gli1 expressions. Altered expression of Gli1, SMO, PTCH1, and HHIP caused by EGOT overexpression were fully restored in cells transfected with pcDNA-EGOT and treated with purmorphamine, an agonist of the Hh pathway. Cell viability and migration were also restored under by purmorphamine. We conclude that lncRNA EGOT may inhibit breast cancer cell viability and migration via inactivation of the Hh pathway. This article is protected by copyright. All rights reserved.BACKGROUND Alpha-fetoprotein (AFP), routinely used for diagnosis of hepatocellular carcinoma (HCC), is limited with relatively low sensitivity and high false positivity in HBV-r

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