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https://www.selleckchem.com/products/Estradiol.html rther in vivo and toxicological studies are carried out.Purpose To evaluate the efficacy and safety of laparoscopic nerve-sparing radical hysterectomy (LNSRH) in the treatment of early cervical cancer. Methods The clinical data of 152 patients with early cervical cancer undergoing radical hysterectomy (RH) were retrospectively analyzed, and the patients were divided into LNSRH group (n=76) and laparoscopic RH (LRH) group (n=76) according to the surgical approaches. The tumor recurrence and survival were recorded during postoperative follow-up, and the disease-free survival (DFS) and overall survival (OS) were compared between the two groups of patients. Results The general clinical characteristics were comparable between the two groups of patients. LNSRH group had a remarkably longer operation time (p less then 0.001) and a notably shorter length of hospital stay (p less then 0.001) than LRH group. The postoperative in-dwelling time of urinary catheter in LNSRH group was evidently shorter than that in LRH group (p less then 0.001). Besides, the time of first flatus and defecation after operation was markedly shortened in LNSRH group compared with that in LRH group, with statistically significant differences (p less then 0.001). In comparison with those in LRH group, the incidence rate of bladder dysfunction was obviously decreased (p less then 0.001), while the urodynamic indexes at 6 months after operation were prominently better in LNSRH group (p less then 0.05). According to the follow-up results, the 5-year OS was 84.9% and 88% in LNSRH group and LRH group, respectively, and the DFS was 74.0% and 78.7%, respectively. Log-rank test showed that the differences in OS and DFS between the two groups of patients were not statistically significant (p=0.275, p=0.213). Conclusions LNSRH is safe and effective in treating early cervical cancer and can result in similar tumor recurrence and long-term survival to LRH. Howev

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