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https://www.selleckchem.com/products/pd-1-pd-l1-inhibitor-1.html ctive in a wide range of LAA morphologies, with a low procedural complication rate, high degree of LAA sealing, and favorable short-term efficacy. The aim of this study was to assess the feasibility, efficacy, and clinical outcomes of transcatheter repair of tricuspid regurgitation (TR) in a pooled analysis of interventional studies. New percutaneous devices are available to treat severe TR, but the evidence is sparse and limited to smaller cohorts. Several electronic databases were searched for interventional studies involving percutaneous repair of TR. Devices used were the Cardioband, FORMA, MitraClip, PASCAL, and Trialign. Outcomes included in the final analysis were successful implantation, residual severe TR, post-procedural New York Heart Association (NYHA) functional class III or IV, 6-min walk distance, and echocardiographic parameters. Subgroup and meta-regression analysis were performed to further explore residual heterogeneity. Seven studies and 454 patients undergoing transcatheter tricuspid valve repair were included in the pooled analysis; 95% of patients had at least severe TR, and 91% were in NYHA functional class III or IV. Successful implantation was achieved in 86% of patients. At the longest follow-up available (weighted mean 265days), 9% had died. Compared with baseline, a significantly lower proportion of patients had at least severe TR (relative risk 0.38; 95% confidence interval 0.20 to 0.70; p=0.004) and were in NYHA functional class III or IV (relative risk 0.23; 95% confidence interval 0.20 to 0.30; p<0.001). Patients also experienced increases in 6-min walk distance (mean difference+64.6 m; p<0.001) and significant reductions in tricuspid valve annular diameter (mean difference-3mm; p<0.001), while left and right ventricular function did not change significantly. A strategy of transcatheter repair for severe TR appears to be feasible, effective, and associated with improved

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