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https://www.selleckchem.com/EGFR(HER).html We measure the association kinetics of unlabeled L-Tym by detecting its influence on the hybridization of the labeled complementary strand. We find that L-Tym slows the association rate of the complementary strand with the aptamer but does not impact its dissociation rate, suggesting an SN1-like mechanism where the complementary strand must dissociate before L-Tym can bind. The competitive model revealed a slow association rate between L-Tym and the aptamer, producing a long-lived L-Tym-aptamer complex that blocks hybridization with the labeled complementary strand. These results provide insight about the kinetics and mechanism of analyte recognition in this structure-switching aptamer, and the methodology provides a general means of measuring rates of unlabeled-analyte binding kinetics in aptamer-based biosensors.Micropatterns of conductive polymers are key for various applications in the fields of flexible electronics and sensing. A bottom-up method that allows high-resolution printing without additives is still lacking. Here, such a method is presented based on microprinting by the laser-induced microbubble technique (LIMBT). Continuous micropatterning of polyaniline (PANI) was achieved from a dispersion of the emeraldine base form of PANI (EB-PANI) in n-methyl-2-pyrrolidone (NMP). A focused laser beam is absorbed by the EB-PANI nanoparticles and leads to formation of a microbubble, followed by convection currents, which rapidly pin EB-PANI nanoparticles to the bubble/substrate interface. Micro-Raman spectra confirmed that the printed patterns preserve the molecular structure of EB-PANI. A simple transformation of the printed lines to the conducting emeraldine salt form of PANI (ES-PANI) was achieved by doping with various acid solutions. The hypothesized deposition mechanism was verified, and the resulting structures were characterized by microscopic methods. The microstructures displayed conductivities of 3.8 × 10-1 S/

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