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https://www.selleckchem.com/products/ly364947.html Primary sarcomas of the chest wall are rare aggressive tumors. Surgery is part of the multimodal treatment. We describe our institutional patient cohort and evaluate prognostic factors. All patients who had curative intent surgery for primary chest wall sarcoma from 2004 to 2019 were retrospectively reviewed. Impact on survival-calculated from the date of surgery until last follow-up- was assessed for the following variables age, gender, type of resection, size, grading, stage, completeness of resection, and neoadjuvant and adjuvant therapy. Twenty-three patients (15 males, 65%) with a median age of 54y (4 to 82) were included. Most common histology was chondrosarcoma (n=5, 22%). Seven patients (30%) received neoadjuvant and 13 patients (57%) received adjuvant treatment. R0 resection was achieved in 83%. Extended chest wall resection was performed in 14 patients (61%), including lung (n=13, 57%), diaphragm (n=2, 9%) and pericardium (n=1, 4%). Morbidity and 90-day mortality were 23% and 0%, respectively. Three- and 5-year overall survival was 53% and 35%, respectively. R0 resection was predictor of overall survival (P=0.029). Tumor grade and extended resections were predictors for recurrence (P=0.034 and P=0.018, respectively). Surgical resection of primary chest wall sarcoma is a safe procedure even when extended resection is required. Surgical resection of primary chest wall sarcoma is a safe procedure even when extended resection is required. Although perforated appendicitis is associated with infectious complications, the choice of antibiotic therapy is controversial. We assess the effectiveness and safety of an intervention to reduce piperacillin and tazobactam (PT) use for pediatric acute perforated appendicitis. This is a single-center, retrospective cohort study of children18y of age or younger who underwent primary appendectomy for perforated appendicitis between January 01, 2016 and June 30, 2019. An interv

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