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https://www.selleckchem.com/products/cb-5339.html The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole genome sequencing of human and environmental strains. Animal strains being poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq, we performed a genomic analysis that included 375 non-duplicated genomes with various origins (animal 104, human 226, environment 30, unknown 15). Phylogenetic analysis and clustering based on genome-wide average nucleotide identity confirmed and specified the genetic organization of Smc in at least 20 genogroups. Two new genogroups were identified and two previously described groups were further divided intd genomic organization was incomplete as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype or MALDI-TOF based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act a reservoir for mobile resistance genes. Some genogroups seem to be clearly associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored. Copyright © 2020 American Society for Microbiology.Burkholderia sp. SG-MS1 and Pseudomonas sp. SG-MS2 have previously been found to mineralize (+)-pinoresinol through a common catabolic pathway. Here we use comparative genomics, proteomics, prot

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