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https://www.selleckchem.com/products/Adriamycin.html Image-guided radiation therapy (IGRT) often relies on EUS-guided fiducial markers. Previously used manually backloaded fiducial needles have multiple potential limitations including safety and efficiency concerns. Our aim was to evaluate the efficacy, feasibility, and safety of EUS-guided placement of gold fiducials using a novel preloaded 22-gauge needle, compared with a traditional, backloaded 19-gauge needle. This was a single-center comparative cohort study. Patients with pancreatic and hepatobiliary malignancy who underwent EUS-guided fiducial placement between October 2014 and February 2018 were included. The main outcome was the technical success of fiducial placement. Secondary outcomes were mean procedure time, fiducial visibility during IGRT, technical success of IGRT delivery, and adverse events. A total of 114 patients underwent EUS-guided fiducial placement during the study period. Of these, 111 patients had successful placement of a minimum of 2 fiducials. 56 patients underwent placement ue, safe, and allows for a higher number of fiducials placed when compared with the traditional backloaded 19-gauge needle. By different mechanisms, image enhancement techniques (linked color imaging [LCI]) and mucosal exposure devices (Endocuff-assisted colonoscopy [EAC]) can improve the adenoma detection rate (ADR) during screening colonoscopy. The impact of the combination of the 2 techniques has never been studied. This study aimed to compare the ADR between the combination of LCI and EAC (LCI+EAC), LCI alone, EAC alone, and standard high-definition colonoscopy (SC). This prospective randomized controlled trial included participants who underwent screening colonoscopy. Participants were randomized to LCI+EAC, LCI, EAC and SC. All colonoscopies were performed by endoscopists with a recorded ADR ≥35%. The primary outcome was the ADR. The secondary outcomes were proximal detection rate (pADR) and the mean number of

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