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https://www.selleckchem.com/products/mmaf.html The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Clinical charts and microbiological reports of the clinical cases. Case 1 included a left ventricular assist device (HEARTMATE 3™Abbot ) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. The goal of this study was to investigate the prevalence and factors associated with persistent viral shedding (PVS) in hospitalized patients with severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) infection. This was a prospective observational study including all consecutive adults hospitalized with SARS-CoV-2 infection. When the first nasopharyngeal swab was positive for SARS-CoV-2 RNA (day0), additional samples were obtained on days+ 3, + 5, + 7 and then once every 7days until virus detection was negative. PVS was defined as the duration of shedding of at least 21days after diagnosis. The primary endpoint of this study was the prevalence of PVS. Data were obtained regarding 121 consecutive hospitalized patients with SARS-CoV-2 infection (median age 66years, male sex 65.3%). Ov

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