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https://www.selleckchem.com/products/usp22i-s02.html Chrysomycin A (CA) has been reported as numerous excellent biological activities, such as antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good amphiphilicity and potential anticancer effect of disodium glycyrrhizin (Na GA) as an excipient, an amorphous solid dispersion (Na GA/CA-BM) consisting of CA and Na GA was prepared in the present study by mechanochemical technology (roll mill ML-007, zirconium balls, 30rpm, 2.5h) to improve the solubility and oral bioavailability of CA. Then, Na GA/CA-BM was self-assembled to micelles in water. The interaction of CA and Na GA in solid state were investigated by X-ray diffraction studies, polarized light microscopy, and scanning electron microscope. Meanwhile, the properties of the sample solution were analyzed by dynamic light scattering and transmission electron. Furthermore, the oral bioavailability and antitumor ability of Na GA/CA-BM in vivo were tested, providing a theoretical basis for futurgesting a potential formulation for efficient anticancer treatment. Reducing poverty and improving access to health care are two of the most effective actions to decrease maternal mortality, and conditional cash transfer (CCT) programmes act on both. The aim of this study was to evaluate the effects of one of the world's largest CCT (the Brazilian Bolsa Familia Programme (BFP)) on maternal mortality during a period of 11 years. The study had an ecological longitudinal design and used all 2548 Brazilian municipalities with vital statistics of adequate quality during 2004-2014. BFP municipal coverage was classified into four levels, from low to consolidated, and its duration effects were measured using the average municipal coverage of previous years. We used negative binomial multivariable regression models with fixed-effects specifications, adjusted for all relevant demographic, socioeconomic, and healthcare variables

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