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https://www.selleckchem.com/products/ccs-1477-cbp-in-1-.html 40 patients in group A and 25 in group B had intraoperative awareness. 1 patient in group A and 3 in group B had vomiting and 1 patient in group B was presented with the hallucinations. CONCLUSION Overall use of ketamine is associated with better sedation and no significant side effects with low doses of ketamine, were seen in our study. Comparative studies using other analgesics, with larger sample size are therefore recommended. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIMS Development of novel anti-breast cancer agents. BACKGROUND Breast cancer, caused by the development of malignant cells in the breast, is the most common invasive cancer and the second leading cause of cancer death in women after lung cancer. One in eight women worldwide develop breast cancer during their lifetime, and the International Agency for Research on Cancer estimated that breast cancer resulted in 2.1 million new cases and 627,000 deaths in 2018. Anticancer agents are critical for the treatment of breast cancer, but the cost is pretty high mean per patient per month costs of breast cancer were to be $2,896 (median $1,940). Moreover, the increasing emergency of drug-resistant breast cancers and the toxic side effects of the drugs have already put heavy burden on the effective control and eradication of breast cancers. OBJECTIVE The primary objective of this study was to evaluate the potential of bis-isatin scaffolds with alkyl/ether linkers between the two isatin moieties against different human breast cancer cell lines including MCF-7, AU565, MDA-MB-231, MDA-MB-435 and MDA-MB-468 cells. METHOD The bis-isatin scaffolds 4, 8 along with the references Doxorubicin and Cisplatin were evaluated for their in vitro activity against MCF-7, AU565, MDA-MB-231, MDA-MB-435, and MDA-MB-468 human breast cancer cell lines by MTT assay. RESULT The bis-isatin scaffolds 4 and 8 were sensitiv

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