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https://www.selleckchem.com/products/gdc-0068.html We report four studies (N=1419) examining emotional reactions from March to April 2020, when COVID-19 exhibited exponentially increasing infections and fatalities. Specifically, we examined associations between emotions with self-reported intentions to enact virus-prevention behaviors that protect oneself from COVID-19 and eudaimonic functioning. Study 1A, 1B, and Study 2 provided naturalistic evidence that mixed emotions predicted legitimate virus-prevention behaviors and eudaimonic functioning in the USA and Singapore, and Study 2 also supported receptivity as a mediator. Finally, Study 3 provided experimental evidence that mixed emotions causally increased legitimate virus-prevention behaviors relative to neutral, positive emotion, and negative emotion conditions, whereas eudaimonic functioning was increased only relative to the neutral condition. Across all studies, positive and negative emotions were unrelated to legitimate virus-prevention behaviors, while relationships with eudaimonic functioning were inconsistent. While self-reported measures do not represent actual behaviors, the findings suggest a potential role for mixed emotions in pandemic-related outcomes. The online version contains supplementary material available at 10.1007/s42761-021-00045-x. The online version contains supplementary material available at 10.1007/s42761-021-00045-x.Prostate cancers are considered to be immunologically 'cold' tumors given the very few patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of interferon-stimulated genes (ISGs) predicted a favorable response to CPI across various disease sites. The enhancer of zeste homolog-2 (EZH2) is overexpressed in prostate cancer and known to negatively regulate ISGs. In the present study, we demonstrate that EZH2 inhibition in prostate cancer models activates a double-stranded RNA-STING-ISG stress response upregulating genes involved in antigen presenta

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