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https://www.selleckchem.com/products/bemnifosbuvir-hemisulfate-at-527.html We extracted and purified three polysaccharides from Echinacea purpurea using pectinase-assisted extraction to obtain crude preparations and optimized the method using an orthogonal analysis. We obtained three polysaccharide fractions (EPPS-1, -2 and -3) using DEAE ion exchange and gel filtration chromatography. The homogeneity of the fractions was confirmed using high performance gel permeation chromatography. EPPS-3 administered to mice in a LPS-induced septicemia model effectively counteracted the effects of LPS resulting in significantly less lung damage. This trend was also seen in the serum and lung cytokine levels where EPPS-3 significantly decreased the levels of TNF-α and IL-6 and increased IL-10. Particularly, we fully characterized the structure of the EPPS-3 polysaccharide using a series of technologies. This polysaccharide structure was mainly composed of →4)-α-Glcp-(1→, →4)-α-Galp-(1→, T-α-Araf-(1→, →3,4)-β-GalpA-(1→ glycosidic linkages at a certain proportion. In sum, EPPS-3, with a clear structure, has potent anti-inflammatory activities and is a candidate for further development as an anti-inflammatory agent for clinical development.The abundance of water on earth provides a large window to utilize the mechanical energy within river currents and ocean waves. In this regard, hydropower harvesting through solid-liquid contact electrification has received considerable interest in the recent past. Despite advancements in nanotechnology, liquid energy harvesting devices, especially solid-liquid triboelectric nanogenerators (S-L TENGs), require efficient engineering of the interfacial properties of their substrates to transfer liquid mass and momentum rapidly with the effective generation/transfer of surface charges. To face this challenge, several parameters such as the selection of material, surface morphology and surface properties are currently being studied to develop a better

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