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https://www.selleckchem.com/products/OSI-906.html sible as oral drug carriers of exenatide and have the potential to be extended to other drugs that are not readily oral, such as monoclonal antibodies, vaccines, genes, etc., thus, this would be beneficial for pharmaceutical industries. Further research will focus on the biodistribution of Bio-TMC/HP-55 nanoparticles after oral administration. Metformin, an anti-diabetic drug, has low bioavailability and a short biological half-life. Thus, bioavailability enhancement and prolonged release of the drug are highly desirable. In this regard, we aimed to developed gastroretentive nanoparticles made of jackfruit seed starch (JFSS) loaded with metformin. The developed nanoparticles were optimized for various process variables and were further characterized. Nanoparticles exhibited good results with respect to particle size (244.3 to 612.4 nm), particle size distribution, shape, and drug entrapment efficiency (75.8 to 89.2 %) with sustained drug release for 24 h and a high buoyancy (89% for F7, formulation made of the highest concentration of Jackfruit seed starch prepared at 1000 RPM stirring speed). The hypoglycemic potential of these nanoparticles was tested in the nicotinamide streptozocin induced diabetic model; there was a significant reduction in blood glucose level (50 % reduction from 4 - 8 h, p < 0.01) for a prolonged period of time (up to 24 h) in comparison to diabetic control and plain metformin solution. The outcome of the study suggested that the developed formulations are suitable for gastro-retentive delivery of Metformin in a controlled manner appropriate for a single administration per day. The outcome of the study suggested that the developed formulations are suitable for gastro-retentive delivery of Metformin in a controlled manner appropriate for a single administration per day. The present research work was aimed to formulate fast disintegrating tablets (FDTs) of salbutamol sulphate (SBS) using a combi

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