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https://www.selleckchem.com/products/Deforolimus.html 001), and between axial and lateral loadings (  < .001). Conventional preparation recorded 2914 N under axial loading and 1516 N under lateral loading, while modified preparation recorded 3329 N under axial loading and 1871 N under lateral loading. FEA showed that retention grooves have reduced the stress concentration under both loads for the tooth and the restoration. Modified endocrown design showed higher fracture resistance than conventional endocrown. Lateral loading displayed a high percentage of severe fracture but under higher load to failure than the values reported for normal masticatory forces. Modified endocrown design showed higher fracture resistance than conventional endocrown. Lateral loading displayed a high percentage of severe fracture but under higher load to failure than the values reported for normal masticatory forces. To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against . The antimicrobial efficacy of the silver nanoparticles was determined by the standard methods of Clinical and Laboratory Standards Institute (CLSI). Different concentrations of silver nanoparticles were prepared, and MIC was calculated by tube macro-dilution method. The MBC was determined by the lowest concentration that kills 99.9% of the initial bacterial population. The data were analyzed by ANOVA and Tukey's test using SPSS software. The MIC and MBC of silver nanoparticles against was found to be 0.625 mg/ml. The result obtained from this study shows that silver nanoparticles have potential bactericidal effects against at a concentration of 0.625 mg/ml. Silver nanoparticles can be incorporated in the root canal medicaments, sealers and irrigants as it possess potent antimicrobial efficacy against . The result obtained from this study shows that silver nanoparticles have potential bactericidal effects against S. aureus at a concentration o

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