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https://www.selleckchem.com/ Motor imagery modulates specific neural oscillations like actual movement does. Representatively, suppression of the alpha power (e.g., event-related desynchronization [ERD]) is the typical pattern of motor imagery in the motor cortex. However, in addition to this amplitude-based feature, the coupling across frequencies includes important information about the brain functions and the existence of such complex information has been reported in various invasive studies. Yet, the interaction across multiple frequencies during motor imagery processing is still unclear and has not been widely studied, particularly concerning the non-invasive signals. In this study, we provide empirical evidence of the comodulation between the phase of alpha rhythm and the amplitude of high gamma rhythm during the motor imagery process. We used electroencephalography (EEG) in our investigation during the imagination of left- or right-hand movement recorded from 52 healthy subjects, and quantified the ERD of alpha and phase-amplitude In the evaluation, WCFC with only two electrodes yielded a performance comparable to the conventional algorithm with 64 electrodes in classifying left and right-hand motor imagery. These results indicate that the phase-amplitude frequency plays an important role in motor imagery, and that optimizing this frequency ranges is crucial for extracting information features to decode the motor imagery types.Prevention or modification of acquired epilepsy in patients at risk is an urgent, yet unmet, clinical need. Following acute brain insults, there is an increased risk of mesial temporal lobe epilepsy (mTLE), which is often associated with debilitating comorbidities and reduced life expectancy. The latent period between brain injury and the onset of epilepsy may offer a therapeutic window for interfering with epileptogenesis. The pilocarpine model of mTLE is widely used in the search for novel antiepileptogenic treatments. Recent biochemi

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