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https://www.selleckchem.com/products/mk-8617.html We explored the influence of low-dose intravenous alteplase and intensive blood pressure lowering on outcomes of acute ischemic stroke according to status/location of vascular obstruction in participants of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). ENCHANTED was a multicenter, quasi-factorial, randomized trial to determine efficacy and safety of low- versus standard-dose intravenous alteplase and intensive- versus guideline-recommended blood pressure lowering in acute ischemic stroke patients. In those who had baseline computed tomography or magnetic resonance imaging angiography, the degree of vascular occlusion was grouped according to being no (NVO), medium (MVO), or large (LVO). Logistic regression models were used to determine 90-day outcomes (modified Rankin scale [mRS] shift [primary], other mRS cut-scores, intracranial hemorrhage, early neurologic deterioration, and recanalization) by vascular obstruction status/site. Heterogeneity in associations for outcomesion status/site according to analyses from ENCHANTED, although these results are compromised by low statistical power. http//www.clinicaltrials.gov. Unique identifiers NCT01422616. Functional outcome by dose of alteplase or intensity of blood pressure lowering is not modified by vascular obstruction status/site according to analyses from ENCHANTED, although these results are compromised by low statistical power.Clinical Trial Registration http//www.clinicaltrials.gov. Unique identifiers NCT01422616.The present study investigated the moderator role of multidimensional wisdom (i.e. individuals' positive personality traits) on the association between caregiver burden and depressive symptoms among family caregivers of disabled older adults in China.A quota sampling was used to recruit 789 pairs of disabled older adults and their primary family caregivers in Shanghai, China, in 2013. Multiple-group path analysis was used

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