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https://www.selleckchem.com/products/sb273005.html Reconstruction of mandibular discontinuity defects remains a challenge for maxillofacial surgeons. Despite vascularized free flaps representing the current gold standard for managing such defects, the search continues for other less morbid yet predictable interventions. This study aimed at reviving the idea of alloplastic mandibular endoprosthesis as a treatment modality for reconstruction of segmental mandibular defects following eradication of benign tumors. To reconstruct their segmental mandibular defects, this case series compiled seven patients who received patient-specific titanium implant (PSI) with osseointegrated components and were designed to receive a restoration for dental rehabilitation. The recruited patient population was followed-up for a period of 3-5 years. Three of the seven PSIs failed due to extensive intraoral mucosal dehiscence or persistent extraoral fistulae. Patients with the 4 surviving PSIs enjoyed good results in terms of occlusion, masticatory function, mouth opening as well as pleasing facial esthetics. The described technique represents a viable less morbid alternative to the standard bone grafting techniques for mandibular reconstruction in carefully selected patients. Further studies are needed to modify the PSI design and surface treatment for better outcomes. Cannabis use has increased in the last decade, and the impact of cannabis on female sexual function remains unclear. To assess the impact of frequency of use, chemovar (tetrahydrocannabinol, cannabinol, or both) type, and method of consumption on female sexual function among cannabis users. Adults who visited a single-partner cannabis dispensary's locations were invited to participate in an uncompensated, anonymous online survey October 20, 2019 and March 12, 2020. The survey assessed baseline demographics, health status, cannabis use habits as well as used the validated Female Sexual Function Index (FSFI) to assess sexual

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