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https://www.selleckchem.com/EGFR(HER).html The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.Increasing frequencies of droughts require proactive preparedness, particularly in semi-arid regions. As forecasting of such hydrometeorological extremes several months ahead allows for necessary climate proofing, we assess the potential economic value of the seasonal forecasting system SEAS5 for decision making in water management. For seven drought-prone regions analyzed in America, Africa, and Asia, the relative frequency of drought months significantly increased from 10 to 30% between 1981 and 2018. We demonstrate that seasonal forecast-based action for droughts achieves potential economic savings up to 70% of those from optimal early action. For very warm months and droughts, savings of at least 20% occur even for forecast horizons of several months. Our in-depth analysis for the Upper-Atbara dam in Sudan reveals avoidable losses of 16 Mio US$ in one example year for early-action based drought reser

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