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https://www.selleckchem.com/products/ms-275.html Aim To investigate the efficacy of adjuvant chemotherapy plus tumor-infiltrating lymphocytes (TILs) therapy in osteosarcoma patients with a poor response to neoadjuvant chemotherapy. Materials & methods 40 patients received adjuvant chemotherapy (Group 1) and 40 patients received adjuvant chemotherapy plus TILs therapy (Group 2). Disease-free survival (DFS) and overall survival (OS) were analyzed by Kaplan-Meier analysis. Results The median DFS (mDFS; 65.3 months) and median OS (mOS; 95.8 months) in Group 2 were significantly prolonged compared with those in Group 1 (55.5 months for mDFS and 80.4 months for mOS). Univariate and multivariate analyses indicated that a greater number of TILs transfused was an independent prognostic factor for both mDFS and mOS. Conclusion Adjuvant chemotherapy plus TILs therapy may prolong survival of patients with a poor response to neoadjuvant chemotherapy.Objective This study aimed to assess the positional relationships between the maxillary sinus and the first and second molars in a western Chinese population by using cone-beam computed tomography. Methods This study included 212 patients (652 maxillary molars and 1956 roots). Patient demographics (sex and age) and cone-beam computed tomography data regarding the relationship between molar roots and the maxillary sinus were obtained. This relationship was stratified into four types for statistical analysis. Results Sex and side did not significantly influence the distance between maxillary molar roots and the maxillary sinus. However, the distance between maxillary molar roots and the maxillary sinus increased with age. The mesiobuccal root of the second molar was nearest to the maxillary sinus. The most common relationship type involved absence of root contact with the sinus border and presence of a maxillary sinus cross-section above the root apex. Conclusions Compared with other teeth, the maxillary posterior teeth have a complex

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