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https://www.selleckchem.com/GSK-3.html 43; 95% CI .062 - 3.32; p=.3989). Among CD patients treated anti-TNF-α medications an increase in the incidence of MS, compared to CD patients not exposed to such medications was observed (IRR=2.62; 95% CI 1.00 to 6.83; p=0.049), statistically significant. After adjusting for age/gender, patients with CD using anti-TNF-α agents had an increase of incidence in MS (adjusted IRR 2.24; 95% CI 0.85 - 5.94; p=.1035) but it was not statistically significant. Use of anti-TNF-α drugs in CD was associated with a statistically significant increase in the incidence of MS but this effect was lost when controlled for age/gender. Use of anti-TNF-α drugs in CD was associated with a statistically significant increase in the incidence of MS but this effect was lost when controlled for age/gender. Total knee arthroplasty is a very successful standard treatment for severe osteoarthritis. Nevertheless, the literature reports tibial debonding between implant and bone cement as well as radiolucent lines related to the tibial components of different knee systems. Regardless of cementing techniques and the influences during surgery, we examined the design of a newly developed knee system and its predecessors (Attune, Attune S+, P.F.C. Sigma, P.F.C. Sigma RP/M.B.T., all DePuy). We investigated the dimensions of the tibial components and the fit between them and their bone bed after instrumentation in a foam material. Our results showed considerable differences for the used knee prostheses as well as their tibial instrumentation options with a corresponding risk for incomplete seating. The orthopedic surgeons need to be aware of these design features and the resulting increased seating resistance especially in hard and sclerotic bone. Comparison of the tibial instruments and the different design options of the Attune knee system and its predecessor knee prostheses. The Attune implant showed incomplete seating because of too much press fit and an uneven b

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