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https://www.selleckchem.com/products/cytosporone-b.html he RIC Flu/TBI platform for lymphomas. Allogeneic stem cell transplantation is applied to patients suffering from hematological malignancies to replace the diseased hematopoietic system with cells derived from a donor stem cell graft. The majority of 10/10 matched unrelated donors are HLA-DP-mismatched and this may result in varying degrees of graft-versus-leukemia (GVL) effect with or without the occurrence of graft-versus-host disease (GVHD). Allo-HLA-reactive T cells are commonly present in the donor T-cell repertoire and therefore a very profound allo-reactive immune response can be provoked in the HLA-DP-mismatched setting. The magnitude and the diversity of the allo-HLA-DP-specific immune response likely dictates the balance between the occurrence of GVL and/or GVHD after transplantation. To understand the nature of the allo-HLA-DP-specific immune response provoked under different stimulatory conditions, immune responses were induced from both the naïve and memory T-cell compartment using either HLA-DP-mismatched professional (monocyte-derived dendritic cells, alloDC) or HLA-DP-mismatched non-professional APC (skin-derived fibroblasts, alloFibroblasts) as stimulator cells. In this study we observed that allo-HLA-DP-reactive T cells could be provoked from both the naïve and memory compartment by both types of APC. However, the magnitude of the allo-HLA-DP-specific immune response was greater when stimulation was performed with alloDC. Moreover, we found that the frequency of allo-HLA-DP-reactive T cells was greater in the naïve T-cell compartment compared to the memory T-cell compartment, but we observed a comparable lineage specificity of these allo-HLA-DP-specific reactivities. Overall, the data in this study illustrate that the presence of professional APC of recipient origin will mostly dictate the magnitude of the allo-HLA-DP-specific immune response derived from both the naïve and memory T-cell compa

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