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https://www.selleckchem.com/ We aimed to assess the effects of safinamide on depression, motor symptoms, and the serotonin syndrome related to its co-administration with antidepressants in patients with Parkinson's disease (PD). We retrospectively analyzed the data of patients at 1 and 3 months of follow-up compared to baseline. = 82 (safinamide 50 mg = 22, 100 mg = 60, with antidepressants = 44). First, we found improvement in depression (Hamilton Depression Rating Scale -6 ± 5.10 at 1 month and -7.27 ± 5.10 at 3 months, < 0.0001; Patient Global Impression of Improvement Scale 60.3% and 69.5% of patients at 1 and 3 months reported some improvement). Second, safinamide improved the daily life activities and motor symptoms/motor complications (Unified Parkinson's Disease Rating Scale (UPDRS-II) -2.51 ± 6.30 and -2.47 ± 6.11 at 1 and 3 months, < 0.0001; III -3.58 ± 8.68 and -4.03 ± 8.95 at 1 and 3 months, < 0.0001; IV -0.61 ± 2.61 and -0.8 ± 2.53 at 1 and 3 months, < 0.0001). Third, 7.31% and 8.53% of patients developed non-severe adverse events related to safinamide at 1 and 3 months. Serotonin syndrome was not observed in the patients treated with antidepressants; some isolated serotonin syndrome symptoms were reported. Safinamide could be useful for treating depression in PD; it was effective for motor symptoms and motor complications and safe even when co-administered with antidepressants. Safinamide could be useful for treating depression in PD; it was effective for motor symptoms and motor complications and safe even when co-administered with antidepressants.Holotrichia parallela (Coleoptera Scarabaeidae Melolonthinae) is a notorious pest of many crops, especially peanuts. In this study, volatiles from peanut plants were analyzed using both gas chromatographic-electroantennographic detection (GC-EAD) and gas chromatography/mass spectrometry (GC/MS) techniques, and tested for adult attraction with field trapping bioassays in Hebei Province, China. GC-EAD analyses

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