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https://www.selleckchem.com/products/LY294002.html 44 (95% CI 0.22, 0.87)] and high fibre intake [HR 0.60 (95% CI 0.36, 0.99)] were associated with a lower hazard of CVD. Reduction in fat intake following T2D diagnosis modified associations with CVD. In particular, among those with the highest fat intake, decreasing intake attenuated the association with CVD [HR 0.75 (95% CI 0.36, 1.56)]. Following T2D diagnosis, decreasing fat intake was associated with lower long-term CVD risk. This evidence may raise concerns about low-carbohydrate, high-fat diets to achieve weight loss following T2D diagnosis. Further research considering the sources of fat is needed to inform dietary recommendations. This trial is registered as ISRCTN86769081. Retrospectively registered on 15 December 2006. This trial is registered as ISRCTN86769081. Retrospectively registered on 15 December 2006. In addition to systemic inflammatory response syndrome (SIRS), various clinical signs, microbiological findings and inflammatory markers could be associated with severe diabetic foot infections (DFI). This study included a retrospective cohort of 245 patients with DFI treated at San Juan de Dios Hospital in San José de Costa Rica. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), CRP/albumin ratio, peripheral blood leucocyte ratios and the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system were evaluated. Univariate analysis was carried out between moderate and severe infections. ROC curves were plotted. Cut-off value of inflammatory markers for diagnosing severe infections was established and then dichotomized to be included in a logistic regression model. A score was designed based on its results. Skin necrosis (p<0.01, OR=8.5, 95% CI=3.5-20.9), ESR>94mm/h (p<0.01, OR=2.5, 95% CI=1.2-5.1), albumin<2.8g/dl (p=0.04, OR=2.0, 95% CI=1.0-4.1) and neutrophias mild, moderate, severe without SIRS and severe. A post hoc subgroup analysis of two phase III trials (NCT0041

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