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https://www.selleckchem.com/products/azd-1208.html A timely understanding of the relationship between the disease and the digestive system and implementing effective preventive measures are of great significance for a favorable outcome of the disease and can help mitigate further transmission by appropriate measures. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.One nucleotide substitution in codon 87 of HLA-DQB1*05020101 results in a novel allele, HLA-DQB1*05116. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Bipolar disorder (BD) is a mental disorder characterized by extreme changes in mood polarity. It is also characterized by cognitive and metabolic dysfunctions. Fibroblast growth factor 21 (FGF21) is an endocrine protein that has a multifaceted function such as glucose and lipid regulation in the periphery, and neuroprotection and induction of synaptic plasticity in the central nervous system. Previous studies reported inconsistent results concerning peripheral FGF21 levels in patients with BD. In this study, we compared plasma FGF21 levels between 26 patients with BD and 51 healthy controls using a human FGF21 ELISA Kit. There was no significant difference in plasma FGF21 levels between the patients and controls. We found significant positive correlations between plasma FGF21 levels and some cognitive parameters (word association and motor speed). If our results are replicated that higher peripheral FGF21 may be associated with better cognitive performance in patients with BD. © 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology.The central nervous system (CNS) is composed of precisely assembled circuits which support a variety of physiological functions and behaviors. These circuits include multiple subtypes

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