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https://www.selleckchem.com/products/cpi-0610.html 98, and 2.43, respectively, P less then 0.021), as was BMI in the upper quartile (HR = 2.59, 2.91, and 2.29, respectively, P less then 0.013).Conclusion BMI in the lower and upper quartiles at diagnosis and during follow-up was associated with a more severe disease course in children with IBD.What is Known• Inflammatory bowel disease (IBD) has been associated with underweight and malnutrition.• The impacts of weight and body mass index (BMI) on the presentation and course of IBD have been mainly investigated in the adult population.What is New• In the era of the obesity epidemic, this study identifies both low and high BMIs at diagnosis and at follow-up as a marker for poor outcome in pediatric IBD.• The results support using BMI as a predictor of IBD course and prognosis.The Rescorla-Wagner (R-W) model describes human associative learning by proposing that an agent updates associations between stimuli, such as events in their environment or predictive cues, proportionally to a prediction error. While this model has proven informative in experiments, it has been posited that humans selectively attend to certain cues to overcome a problem with the R-W model scaling to large cue dimensions. We formally characterize this scaling problem and provide a solution that involves limiting attention in a R-W model to a sparse set of cues. Given the universal difficulty in selecting features for prediction, sparse attention faces challenges beyond those faced by the R-W model. We demonstrate several ways in which a naive attention model can fail explain those failures and leverage that understanding to produce a Sparse Attention R-W with Inference framework (SAR-WI). The SAR-WI framework not only satisfies a constraint on the number of attended cues, it also performs as well as the R-W model on a number of natural learning tasks, can correctly infer associative strengths, and focuses attention on predictive cues while ignoring

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