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https://www.selleckchem.com/products/cabotegravir-gsk744-gsk1265744.html The addition of SC increased the gene expression of several potential targets, including STAT3, KDR, CASP3, and TGFB1. In addition, SC administration elevated the protein expression of p-AKT and inhibit the protein expression of p-ERK, but has no impact on the protein expression of p-P38. Moreover, SC could improve haemogram parameters, coagulation indicators, and the proliferation and differentiation of MK in the ITP animal model. The present study systematically elucidated the underlying mechanisms of SC against ITP and provided an efficient strategy to discover the pharmacological mechanism of TCM. It may strengthen the understanding of SC and facilitate more application of this formula in the treatment of ITP. The present study systematically elucidated the underlying mechanisms of SC against ITP and provided an efficient strategy to discover the pharmacological mechanism of TCM. It may strengthen the understanding of SC and facilitate more application of this formula in the treatment of ITP. Cardiac fibrosis is a major structural change observed in the heart of patients with type 2 diabetes mellitus (T2DM), ultimately resulting in heart failure (HF). Suppression of inflammation is an effective therapeutic strategy for treating cardiac fibrosis and HF. Gentiopicroside (GPS), the primary component of Gentiana manshurica Kitagawa, possess potent anti-inflammatory activity. However, its cardioprotective role remains elusive. We explored the potential cardioprotective role of GPS in T2DM rats and its underlying mechanisms. T2DM rats built by high-fat diet and streptozotocin were orally administered 25, 50, or 100mg/kg GPS, daily for 8 weeks. The positive control drug was Metformin (200mg/kg/day). Primary cardiac fibroblasts (CFs) were induced by high glucose (30mM) and subsequently treated with GPS (100μM). Cardiac function and pathological changes were analyzed using echocardiography and histo

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