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https://www.selleckchem.com/products/bb-94.html 05) . The serum levels of leptin in patients with second stage and third stage silicosis were higher than those in the control group and first stage, the differences were statistically significant (P less then 0.05) . Serum levels of TGF-β1 in all stage silicosis patients were higher than those in the control group, and third stage silicosis was higher than first stage, the differences were statistically significant (P less then 0.05) . There was a positive correlation between serum levels of leptin and TGF-β1 in silicosis group (r(s)=0.400, P less then 0.05) . The ROC area of leptin and TGF-β1 combined to predict silicosis was 0.826, with the sensitivity and specificity were 73.10% and 80.00%. Conclusion The levels of serum leptin and TGF-β 1 are related to different stages of silicosis, and the combined detection of leptin and TGF-β 1 can assist the diagnosis of silicosis.Objective To explore the application of the Short Form of Quality of Life (SF-36) scale in the investigation of quality of life of occupational disease patients. Methods In May 2019, SF-36 scale was used to investigate the occupational disease patients diagnosed in Hangzhou. The reliability of the scale was evaluated by Cronbach's α coefficient, and the validity of the scale was evaluated by exploratory factor analysis. Results The Cronbach's α coefficients of PF, RP, BP, GH, VT, SF, RE and MH were 0.937, 0.977, 0.870, 0.908, 0.815, 0.701, 0.967 and 0.863 respectively, and the half reliability coefficient α=0.905. The two factor statistics representing physiological and psychological aspects were 0.870, and the approximate chi square value was 1784.337 (P less then 0.01) . Compared with the national norm, the scores of each dimension of quality of life of occupational disease patients were significantly lower, and the differences were statistically significant (P less then 0.01) ; Compared with the scores of each dimension of quality of life of pneu

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