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https://www.selleckchem.com/products/CHR-2797(Tosedostat).html Active lesions type 5 were the most frequent. The indicators for dental status and severity of caries experience increased with age, both with moderate positive correlations. Conclusions Malnourished children under six years old studied in Mendoza presented comorbidity with ECC. Dental status worsened with age. The values for caries indicators demonstrated the weight of caries diagnoses in early stages and the importance of providing preventive measures and systematic monitoring during these children's early years of life.Severe periodontal disease (SPD) associated with systemic peripheral inflammation, cognitive impairment (CI) and arterial stiffness (AS) has been recognized. The aim of this study was to investigate whether CI and arterial stiffness (AS) occur in cardiovascular disease (CVD) patients with SPD. A crosssectional case-control study included hospitalized patients with CVD. Demographic characteristics, CVD and atherogenic risk factors were recorded. SPD was diagnosed by clinical and radiographic dental examinations. Dental clinical attachment level (CAL) and CAL % were recorded. A Mini-Mental State Examination test (MMSE) assessed cognition, a MMSE score of less then 27 was set as the cut-off point of CI; a score ≥ 27 was considered as no CI. Patients were categorized into MMSE less then 27 (cases) and MMSE≥27 (controls). AS was evaluated by pulse wave velocity (PWV). Serum VCAM-1 levels were determined in a random sample. Results This study comprised 91 patients (cases, n=26; 29.6%; controls, n=65, 71.4%); aged 73±8 vs. 73±7 years, respectively (p=0.73), of whom 53.8% and 36.9% respectively, were women; SPD was found to be a risk factor for CI; the presence of SPD increased the risk for MMSE less then 27 by an average 5.39 times (model 1). PWV was associated with MMSE less then 27 in the three models. The risk of having MMSE less then 27 increased an average of 2.404-fold for each 1-unit in

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