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https://www.selleckchem.com/products/cytosporone-b.html 045, both readers). As compared to all other subtypes, the blastemal subtype demonstrated significantly higher skewness (p ≤ 0.022, both readers) and the diffuse anaplastic subtype demonstrated significantly higher 75th-percentile ADC values (p ≤ 0.042, both readers). CONCLUSIONS Diffusion-weighted MRI may be of value in identifying benign nephroblastomatosis and assessing nephroblastoma subtypes. Therefore, further research is warranted to assess its value in risk stratification for pediatric patients with renal tumors in the future.PURPOSE To develop and validate a novel method based on radiomics for the preoperative differentiation of benign and malignant gallbladder polypoid lesions (PLG). PATIENTS AND METHODS A total of 145 patients with pathological proven gallbladder polypoid lesions ≥ 1 cm were included in this retrospective study. All the patients underwent abdominal contrast-enhanced computed tomography (CT) examinations 3 weeks before cholecystectomy from January 2013 to January 2019. Seventy percent of the cases were randomly selected for the training dataset, and 30% of the cases were independently used for testing. Radiomics features extracted from portal venous-phase CT of the PLG and clinical features were analyzed, and the LASSO regression algorithm was used for data dimension reduction. Multivariable logistic regression was used to generate radiomics signatures, clinical signatures, and combination signatures. The receiver operating characteristic (ROC) curve and decision curve were plotted to assess the differentiating performance of the three signatures. RESULTS The area under the ROC curve (AUC) of the radiomics signature and clinical signature was 0.924 and 0.861 in the testing dataset, respectively. For the radiomics signature, the accuracy was 88.6%, with 88.0% specificity and 89.5% sensitivity. When combined, the AUC was 0.931, the specificity was 84.0%, and the sensitivity was 89.5%. T

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