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https://www.selleckchem.com/products/fasoracetam-ns-105.html Furthermore, Gal d 7 cross-reactive allergens were also detected in other poultry species, suggesting that rGal d 7 can be used as a diagnostic marker allergen for poultry meat allergy. The high thermal stability, refolding capacity and resistance to gastrointestinal enzymes might explain why Gal d 7 can act as a potent sensitizing agent. CONCLUSION Gal d 7 represents a novel major chicken meat allergen. Recombinant Gal d 7 could be used for diagnosis of genuine poultry meat sensitization. CLINICAL IMPLICATIONS Myosin light chain 1, designated Gal d 7, was identified as a major chicken meat allergen. Recombinant Gal d 7 can be used for diagnosis of patients primarily sensitized to poultry meat. BACKGROUND Patients with eosinophilic esophagitis have increased numbers of mucosal mast cells. Administration of the proton pump inhibitor omeprazole can reduce both esophageal mast cell and eosinophil numbers and attenuate type 2 inflammation in these subjects. OBJECTIVE Given that maintenance of an acidic environment within granules is important for mast cell homeostasis, we sought to evaluate the effects of omeprazole on mast cell functions including development, IgEFcεRI-mediated activation and responses to food allergen. METHODS Mast cell degranulation, cytokine secretion and early signaling events in the FcεRI pathway, including protein kinase phosphorylation and Ca2+ flux, were measured following IgE crosslinking in murine bone marrow-derived mast cells and human cord blood-derived mast cells. The effects of omeprazole on these responses were investigated as was its impact on mast cell-dependent anaphylaxis and food allergy phenotypes in vivo. RESULTS Murine and human mast cells treated with omeprazole exhibited diminished degranulation and release of cytokines and histamine in response to allergen. In murine mast cells, phosphorylation of protein kinases, ERK and SYK, was decreased. Differentiation of mast

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