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https://www.selleckchem.com/ We have also discussed novel synthetic strategies developed during this period for the synthesis of different indole derivatives. We believe this review article will provide comprehensive knowledge about the medicinal importance of indoles and will help in the design and synthesis of novel indole-based molecules with high potency and efficacy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Inflammatory bowel diseases, including both Crohn's disease and ulcerative colitis are two chronic and progressive disorders affecting the gastrointestinal tract. The current understanding of the molecular mechanisms of these diseases has led to the introduction of targeted therapies which are able to selectively block the key mediators of the inflammation. In particular, research has primarily focused on the development of biologic drugs, but recently, small molecule drugs have been licensed for its use in ulcerative colitis. Janus kinase inhibitors (JAKi) represent the most important family of these drugs, as their peculiar mechanism of action is able to target simultaneously the effects of multiple cytokines and, as a consequence, multiple inflammatory pathways involved in the pathogenesis of the disease are effectively blocked. Here, we discuss the current evidence about the mechanism of action with an up to date review of the efficacy and safety of small molecule drugs in inflammatory bowel disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Background Statins are effective for patients in decreased low-density lipoprotein therapy. Objective We wanted to compare atorvastatin versus rosuvastatin on secondary percutaneous coronary intervention (PCI) rate and explore risk factors in coronary heart disease (CHD) patients. Methods A cohort study with 283 CHD subjects was launched from 2011 to 2015. Cox proportional hazards regression model, Receiver Op

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