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https://www.selleckchem.com/products/cytosporone-b.html ls.OBJECTIVE To evaluate the diagnostic value of ultrasonic measurement of artery peak velocity variation (ΔVpeak) on predicting fluid responsiveness in critically ill patients. METHODS Databases of PubMed, Embase, Cochrane Library, SinoMed, Wanfang, CNKI and VIP were retrieved from the establishment of the database to November 2019. The retrieval literatures were about the research of ΔVpeak used to judge fluid responsiveness. According to the inclusion and exclusion criteria, the relevant literatures were screened by two researchers, and the data of the included literatures were extracted. The quality of literatures was evaluated by quality assessment of diagnostic accuracy studies (QUADAS). Meta Dics 1.4 software was used to analyze the literatures that met the quality standard by Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) were calculated. The summary receiver operating characteristic (SROC) curve was dra 0.004 8]. According to the results of heterogeneity analysis, there was no significant heterogeneity (I2 = 10.6, P = 0.288 5) among the studies after removing the samples of the passive leg raising (PLR) instead of the volume expansion. A meta-analysis was done with random effects model. The results showed that the pooled DOR was 23.85 (95%CI was 17.57 to 32.37), pooled sensitivity was 0.82 (95%CI was 0.80 to 0.85), pooled specificity was 0.83 (95%CI was 0.80 to 0.85), pooled PLR was 4.17 (95%CI was 3.58 to 4.86), and pooled NLR was 0.22 (95%CI was 0.18 to 0.28). The AUC was 0.901 2 (95%CI was 0.88 to 0.93), and Q index was 0.832 5. The results of Deek funnel plot showed that there was no published bias in all the studies (P = 0.19). CONCLUSIONS Ultrasonic measurement of ΔVpeak has a high value in predicting fluid responsiveness. It is a reliable parameter for the evaluation of shock, critical illness a

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