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https://www.selleckchem.com/products/17-AAG(Geldanamycin).html be considered in patients diagnosed with metopic craniosynostosis before 6 months of age. Isotretinoin is prescribed in secondary care for severe acne vulgaris. Anecdotal reports suggest that GPs in Ireland currently initiate isotretinoin. To ascertain the prevalence and management of isotretinoin in Irish general practice and to describe GPs' attitudes about the use of isotretinoin in Ireland. A cross-sectional questionnaire survey of GPs in Ireland between October 2018 and February 2019. Two short questionnaires were developed one for GPs who prescribe isotretinoin and one for GPs who do not prescribe isotretinoin. Questionnaires were distributed via email and online via GP Forum to GPs in Ireland. Of a total 298 GPs who completed the questionnaire, 52 (17%) initiated isotretinoin. Older GPs (aged 35 years) and male GPs were more likely to prescribe isotretinoin. GPs cited prolonged dermatology waiting lists ( = 34, 65%) and a special interest in dermatology ( = 31, 60%) as two key drivers to initiating isotretinoin. However, this study found evidence of suboptimal blood monitoringerence to recommended monitoring. Barriers to and enablers for GPs initiating isotretinoin were identified. Most GPs expressed an interest in initiating isotretinoin. Despite the benefits of relational continuity of care, particularly for patients with multimorbidity, the traditional model of continuity is changing. Revisiting what patients with ongoing problems want from relational continuity could encourage initiatives to achieve these within a modern healthcare system. To examine the attributes of GPs that patients with long-term conditions value most, and which attributes patients believe are facilitated by relational continuity. Qualitative study in UK general practice. A thematic analysis was carried out, based on secondary analysis of interviews with 25 patients with long-term conditions that were originally conducted

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