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https://www.selleckchem.com/screening/kinase-inhibitor-library.html Both unchanged upper cervical lordosis combined with decreased lower cervical lordosis and decreased upper cervical lordosis combined with decreased lower cervical lordosis have been reported to occur after correction surgery for adult spinal deformity. However, variations in cervical alignment after correction surgery in patients with ankylosing spondylitis (AS) have not been investigated. The current study aimed to investigate the variations in cervical alignment following the correction surgery in AS patients with thoracolumbar kyphosis. Patients with AS who underwent pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis from June 2016 to June 2019 with a minimum of 1-year follow-up were reviewed. Patients were grouped according to the presence (ossified group) and absence (non-ossified group) of total ossification of the anterior longitudinal ligament (ALL) in the lower cervical spine. Radiographic parameters, including thoracolumbar, craniocervical, and global radiographic parameters, were m cervical lordosis angle could be achieved by adjusting the osteotomy angle. The variation patterns of cervical alignment following correction surgery for AS-related thoracolumbar kyphosis were different based on patients with or without total ossification of ALL in the lower cervical spine. When planning PSO for patients in the ossified group, restoration of the physiological upper cervical lordosis angle could be achieved by adjusting the osteotomy angle.Some areas in Western Europe indicate hiatuses in human occupations, which cannot be systematically attributed to taphonomic factors and poor site preservation. The site of la Noira in the center of France records two occupation phases with a significant time gap. The older one is dated to around 700 ka (stratum a) with an Acheulean assemblage, among the earliest in Western Europe, and the upper phase of the sequence (stratum c) is dated to ca. 45

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