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https://www.selleckchem.com/products/purmorphamine.html The established norms of Healthy Fitness Measurement Scale (HFMS V1.0) for Chinese urban elderly provide evaluation criteria for Chinese elderly healthy fitness level and facilitate exploration of healthy fitness status and its influencing factors in Chinese urban elderly. To explore the feasibility of three-dimensional (3D) vessel wall imaging of carotid atherosclerotic plaques in ApoE mice using 7.0T magnetic resonance imaging (MRI) with delays alternating with nutations for tailored excitation (DANTE)-prepared fast low-angle shot (DANTE-FLASH) technique. Numerical simulations were performed for optimizing imaging parameters to maximize the wall-lumen contrast. Six ApoE and three wild-type mice were scanned using a 7.0T MRI scanner with DANTE-FLASH and multi-slice 2D RARE coupled with inflow outflow saturation bands (2D-IOSBRARE). The wall signal-to-noise ratio (SNRwall), lumen SNR (SNRlumen), wall-lumen contrast-to-noise ratio (CNR), lumen area (LA), and wall area (WA) were compared between DANTE- FLASH and 2D-IOSB-RARE sequences. Linear regression analysis was performed to assess the correlation between the MRI measurements and histopathological measurements of LA and WA. Based on the simulation results, a flip angle of 15° and a train length of 150 were implemented in the live imaging study. Compared with 2D-IOSB-RARE, DANTE-FLASH provided a slightly reduced CNR ( < 0.001) but much improved slice resolution. The LA and WA measurements from the DANTE-FLASH and 2D-IOSB- RARE showed excellent agreement based on ICC analysis (LA ICC=0.94, < 0.001; WA ICC=0.93, < 0.001) and Bland-Altman plots. Strong correlations were observed between the MRI and histopathological measurements for both LA ( < 0.0001) and WA ( < 0.0001). As a 3D black-blood MR sequence, DANTE-FLASH provides isotropic high spatial resolution to allow reliable visualization and quantitative evaluation of the arteriosclerotic lesions within the car

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