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https://www.selleckchem.com/products/cp2-so4.html All 12 isolates harboured a plasmid carrying the Tn1-bla element, although they were slightly different in size (78 883 bp, 78 898 bp and 78 913 bp) owing to differences in the number of 15-bp repetitive sequences. A 42 542-bp broad-host-range plasmid carrying the Tn1-bla element was also found in one of the isolates. We characterised a plasmid-encoded novel Tn1-bla element and transposon-dependent mechanisms underlying the propagation of antibiotic resistance, together with repeated new polymorphic 15-bp units in the promoter of bla . We characterised a plasmid-encoded novel Tn1-blaTEM-61 element and transposon-dependent mechanisms underlying the propagation of antibiotic resistance, together with repeated new polymorphic 15-bp units in the promoter of blaTEM-61. Antibiotic resistance poses a serious risk in Lebanon, a country with challenges in infrastructure and antibiotic stewardship. Recently, a high prevalence of multidrug-resistant (MDR) Escherichia coli harbouring the mobile colistin resistance gene mcr-1 was reported in faecal matter of poultry in Lebanon. Some of the isolates also exhibited resistance to important antibiotics, including cephalosporins and carbapenems. We performed whole-genome sequencing (WGS) to analyse the genetic determinants of resistance and the sequence types (ST) of five of the isolates. WGS was performed using a MiSeq sequencer. Draft genomes were assembled using SPAdes v.3.9.0. ResFinder v.3.0 and PlasmidFinder v.1.3 databases were used to analyse the acquired resistome and plasmid types, respectively. STs were determined using MLST software. WGS analysis revealed that the strains harboured 9-19 antibiotic resistance genes, including mcr-1.1 and other genes encoding resistance to important antibiotics used in agriculture and huntibiotics in Lebanese poultry and their potential transmission to humans emphasize an urgent need to mitigate the dissemination of antibiotic resistance on

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