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https://www.selleckchem.com/products/sb-204990.html 48, 95% CI 0.66 to 3.34) or liver (HR 1.14, 95% CI 0.54 to 2.41) recipients. Compared to matched controls, donors with infective endocarditis donated fewer organs (2.3 versus 3.2 organs per donor, p<0.001) and were less likely to become kidney donors (OR 0.29, 95% CI 0.16 to 0.55). We found acceptable safety and long-term allograft survival in transplants from selected donors with infective endocarditis in the UK. This may have implications for donor selection and organ utilization. We found acceptable safety and long-term allograft survival in transplants from selected donors with infective endocarditis in the UK. This may have implications for donor selection and organ utilization.Donation after circulatory death determination (DCDD) frequently involves antemortem heparin administration to mitigate peri-arrest microvascular thrombosis. We systematically reviewed the literature to (1) describe heparin administration practices, and (2) explore the effects on transplant outcomes. We searched MEDLINE and EMBASE for studies reporting DCDD heparin practices including use, dosage, and timing (Objective 1). To explore associations between antemortem heparin and transplant outcomes (Objective 2), we (i) summarized within-study comparisons and (ii) used meta-regression analyses to examine associations between proportions of donors that received heparin and transplant outcomes. We assessed risk of bias using the Newcastle Ottawa Scale and applied the GRADE methodology to determine certainty in the evidence. For Objective 1, among 55 eligible studies, 48 reported heparin administration to at least some donors (range 15.8% to 100%) at variable doses (up to 1000 units/kg) and times relative to withdrawal of life sustaining therapy. For Objective 2, seven studies that directly compared liver transplants with and without antemortem heparin reported lower rates of primary nonfunction, hepatic artery thrombosis, graft failure at 5

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