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https://www.selleckchem.com/products/TSU-68(SU6668).html Purpose To understand associations between food insecurity and depression, anxiety, and stress during the COVID-19 pandemic among low-income adults in the United States. Methods During March 19-24, 2020, we fielded a national, web-based survey (53% response rate) among low-income adults ( less then 250% of the federal poverty line) in the United States (N=1,476). Food security status was measured using the 18-question USDA Household Food Security Module. Multivariable-adjusted logistic regression models examined the association between food insecurity and psychological distress outcomes and COVID-19-specific worries. Qualitative data from an open-response question were also analyzed. Results More than one-third of low-income adults screened positive for depression (33%), anxiety (39%), and high stress (39%). Greater food insecurity was associated with a dose-response relationship with all psychological distress outcomes (all outcomes p-trend less then 0.001) and COVID-19-specific worries (all outcomes p-trend less then 0.001). Compared to food-secure adults, adults with very low food security were more likely to screen positive for depression (odds ratio [OR] 7.72; 95% confidence interval [CI] 5.52-10.80), anxiety (OR 6.19; 95% CI 4.51-8.51), and high perceived stress (OR 10.91; 95% CI 7.78-15.30). Very low food security was also associated with increased worries about the effect of COVID-19 on one's health (OR 2.56; 95% CI 1.90-3.45), income (OR 5.18; 95% CI 3.78-7.06), and ability to feed one's family (OR 9.24; 95% CI 6.61-12.92). Conclusions The COVID-19 pandemic is negatively associated with the mental health of low-income adults in the United States, with disproportionate associations among adults experiencing food insecurity. These disparities have the potential to increase mental health disparities over the long term.The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sweeping across

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