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https://www.selleckchem.com/products/dl-thiorphan.html 29 compared to HCV 0.2 (p less then 0.001) and HIV 0.21 (p = 0.037) group. The adjusted analysis where we consider age as possible confounder revealed that only IL-2 significantly differs for all groups compared with control group control vs HCV (p = 0.001); control vs HBV (p = 0.024); control vs HIV (p = 0.004). CONCLUSIONS Evidence for significant differences when comparing oral fluid cytokines of individuals with HCV, HBV and HIV with non-viral individuals was more obvious for IL-2. IL-2 levels were significantly higher in all 3 groups vs non-viral group even when age is confounder. Copyright (c) 2019 Anush Perikhanyan, Vahe Azatyan, Vahe Azatyan, Lazar Yessayan, Melanya Shmavonyan, Gayane Melik-Andreasyan, Kristina Porkshenyan.INTRODUCTION We aimed to investigate the prevalence of liver involvement in pediatric patients with ARI using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury. METHODOLOGY A prospective cohort study of 84 armenian children with ARI was conducted to evaluate the associated liver involvement. The diagnostic variables of interest were the signs of clinical disease severity, and enzymatic profile of the patients. RESULTS Serum levels of OCT were increased in 94% of patients versus routine tests of hepatic panel (AST in 41.7%, ALT in 15.5%, etc). Variance analysis by severity groups showed the serum levels of OCT (p less then 0.001), ammonia (p less then 0.001), phospholipides (p = 0.05), glucose (p = 0.01), TNF-α (p = 0.01), IL-8 (p less then 0.001), AST (p less then 0.001), and ALP (p less then 0.001) were associated with the severity of underlying disease. Moreover, regression analysis revealed the serum activity of OCT (p value less then 0.001, OR = 1.27) and ammonia (p value 0.002, OR = 1.1) significantly predict the severity of the disease. CONCLUSIONS Using more sensitive marker of liver da

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