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https://www.selleckchem.com/products/as1842856.html Advances in cancer biology research led to the identification of new molecular drivers in non-small cell lung cancer. These alterations should be searched especially in young and never-smoker patients, in order to ensure access to targeted therapies. In particular, RET mutations occur in 1-2% of lung adenocarcinomas and represent the molecular target of innovative treatments such as pralsetinib. The Next Generation Sequencing provides a comprehensive genomic profiling both on tissue and blood sampling. The liquid biopsy could be extremely advantageous, as it is a simple, non-invasive and repeatable test. We report the case of a non-smoker woman with metastatic lung adenocarcinoma unresponsive to chemotherapy and immunotherapy. RET mutation (RET-KIF5B fusion) was found by liquid biopsy. The patient started therapy with pralsetinib obtaining an early radiological response and a significant clinical benefit.The discovery of gene driver mutations and the increase of next-generation sequencing techniques have radically changed the natural history of NSCLCs. Neuroendocrine lung cancers are a heterogeneous entity whose biology is little known. Sporadic actionable mutations are also reported in this subtype of neoplasms, especially in tumors derived from a transformation of adenocarcinomas. ROS-1 gene rearrangements are found in about 1-2% of lung neoplasms and are characterized by a high sensitivity to specific tyrosine kinase inhibitors (TKis). Here we report the case of a large cell neuroendocrine carcinoma precisely framed and treated thanks to a next-generation genomic approach. Into blood relatives of patients affected by breast cancer, the prevalence of pancreatic ductal adenocarcinoma (PDAC) seems to be elevated. BRCA1/2 mutations as other VUS (variants of uncertain significance) could be responsible. We retrospectively revised dataset of Pancreatic Surgery Unit of Humanitas Clinical and Research Center - IRCCS and

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