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https://www.selleckchem.com/products/ptc-209.html Pendimethalin, one of the dinitroaniline group herbicides, is applied for controlling weeds in cereals, legumes and vegetable crops, and has been classified as possible human carcinogen. It is indicated that pendimethalin should arise risks of developing some cancer types; however, there is no data on the effects of pendimethalin on pancreatic cancer-induced inflammation. Injuries resulting from by acute pancreatitis attacks and inflammation are significant factors in the development of pancreatic cancer. Therefore, we investigated whether pendimethalin triggers inflammation as a mechanism of pancreatic cancer development. Parameters related to pancreatic activation, oxidative stress, and inflammation were measured in the human pancreatic (PANC-1) cell line. In the range of 0-100 μM, the levels of chymotrypsin decreased. It should be indicated that the reason for the decrease in chymotrypsin may be the high rates of cell death (20%) observed in the high concentration levels. We observed that pendimethalin significantly induced oxidative damage, while levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) did not change. The obtained results may draw attention to the usage and possible toxic effect of pendimethalin due to oxidative damage induction; however, detailed inflammation mechanisms and other cancer pathways should be investigated.This study investigated the possibility of applying pyrolysis as an alternative method to recycle powdered activated carbon-containing water treatment residuals (PAC-WTRs) discharged from the Cheongju water treatment plant as a multifunctional adsorbent. WTRs pyrolyzed for 1 h at 200-700 °C were compared with raw material. The carbon content of the PAC-WTR reaches 19.27%, with about 25% Al and 17% Si. Changes in PAC through pyrolysis imparted new adsorbent properties to WTR. As the pyrolysis temperature increased, the purity of PAC increased, and pores were regenerated to recover th
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